Research library
The research library
Every primary source behind a claim on this site, tier-graded for provenance and tagged for the strength of the evidence it carries.
- Sources indexed
- 221
- Peptides covered
- 44
- Tier 1 share
- 100%
- Matching filter
- 5
F·Filter
Reset allT1·Peer-primary literature
Randomized trials, peer-reviewed primary studies, and meta-analyses — the load-bearing layer of the corpus.
5 sources
- 2026Mechanisticsuggestive
Glycyl-L-histidyl-L-lysine-Cu2+ (GHK-Cu) Attenuates CuSO4 or LPS induced-inflammation in Zebrafish larvae model
Hu J, Zhang C, Wang F · European Journal of Pharmacology
In a zebrafish larvae inflammation model, GHK-Cu suppressed neutrophil and macrophage migration, downregulated TNF-α, IL-1β, and IL-6, upregulated IL-10, and attenuated JAK1 signalling — extending the cosmetic-skin GHK-Cu literature into a whole-organism inflammation readout.
- 2026Mechanisticsuggestive
Anti-inflammatory and anabolic effects of liraglutide on 3D inflammatory osteoarthritic spheroid and scaffold models of human chondrocytes
Ciftci E, Eberlein SC, Grad S, +3 · Osteoarthritis and Cartilage
In 3D human-chondrocyte spheroid and scaffold cultures stimulated with IL-1β, liraglutide reduced IL-8 release roughly four-fold (877.8 vs 3127.0 ng), elevated ACAN and PRG4 anabolic markers, and preserved extracellular-matrix composition under cyclic mechanical loading — the first systematic in-vitro mechanistic case for a direct GLP-1RA effect on osteoarthritic cartilage independent of weight loss.
- 2026Mechanisticsuggestiven=120
Combined antiretroviral therapy with low- or normal-protein, high-calorie diets appears to induce significant deleterious electrocardiographic changes in a rodent model
Chege BM, Mwangi PW, Githinji CG, +1 · Brazilian Journal of Medical and Biological Research
In 120 Sprague-Dawley rats fed calorie-dense diets and dosed with dolutegravir-based or classical combination antiretroviral regimens for 24 weeks, addition of tesamorelin prevented the ECG conduction abnormalities and myocardial fibrosis seen with dolutegravir or classical cART alone — implicating growth-hormone-axis dysfunction in cART-associated cardiotoxicity.
- 2023Mechanisticsuggestiven=30
Thymosin alpha 1 restores the immune homeostasis in lymphocytes during Post-Acute sequelae of SARS-CoV-2 infection
Minutolo A, Petrone V, Fanelli M, +16 · International Immunopharmacology
An ex-vivo study from the Garaci–Matteucci group examining lymphocyte populations in 10 PASC patients, 15 acute-COVID-19 controls, and 5 healthy donors — the only PASC-specific thymosin α-1 paper in the indexed literature, documenting persistent immune dysregulation and partial ex-vivo rescue with greatest effect in patients who had required respiratory support during the acute phase.
- 2015Mechanisticsuggestiven=32
Effect of intra-articular injection of AOD9604 with or without hyaluronic acid in rabbit osteoarthritis model
Kwon DR, Park GY · Annals of Clinical and Laboratory Science
In 32 rabbits with collagenase-induced knee osteoarthritis, combined weekly intra-articular AOD-9604 plus hyaluronic acid produced better histological cartilage and lameness scores than either agent alone — the only published animal-model evidence for AOD-9604's post-obesity-program orthopaedic indication.