Research library
The research library
Every primary source behind a claim on this site, tier-graded for provenance and tagged for the strength of the evidence it carries.
- Sources indexed
- 221
- Peptides covered
- 44
- Tier 1 share
- 0%
- Matching filter
- 6
F·Filter
Reset allT3·Expert-primary work
Domain-expert primary sources outside the journal pipeline — lectures, podcasts, position papers.
6 sources
- 2026Mechanisticsuggestive
Liraglutide alleviates postoperative cognitive impairment via NRF2/NLRP3 signal pathway in aged mice
Sun H, Cheng X, Lei D, +3 · Neuroscience Letters
In aged mice undergoing laparotomy plus transient mesenteric ischemia-reperfusion under sevoflurane, 14 days of liraglutide (300 μg/kg/day) restored Y-maze and fear-conditioning performance, shifted microglia toward an M2 phenotype, preserved synaptic proteins, and activated GLP-1R/NRF2 signalling while suppressing NLRP3 inflammasome — with microglial-depletion experiments showing the mechanism is microglia-dependent.
- 2026Mechanisticsuggestive
Elamipretide (SS-31) promotes recovery by preserving mitochondrial bioenergetics and neural remodeling after spinal cord injury
Song Z, Ban Z, Zhao H, +1 · Neurochemistry International
In a mouse thoracic contusion model of spinal cord injury, the mitochondria-targeting peptide elamipretide (SS-31) improved locomotor recovery and gait performance, reduced lesion pathology, attenuated early apoptotic signaling (lower cleaved caspase-3 / Bax, higher Bcl-2), diminished chronic-stage astrogliosis, and preserved mitochondrial membrane potential plus oxidative-phosphorylation protein integrity in oxidatively stressed PC12 cells.
- 2026Mechanisticsuggestive
IL-15 Plus Thymosin α1 Reduces Senescent Hepatic CD8(+) T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression
Wu F, Guo Z, Guan J, +3 · Journal of Gastroenterology and Hepatology
In aged-mouse orthotopic hepatocellular carcinoma, IL-15 plus Thymosin α1 combination therapy suppressed tumor growth, prolonged survival, and reversed CD8+ T cell senescence by attenuating PI3K/AKT signalling — the first mechanistic study to combine Thymosin α1's thymic-rejuvenation effect with IL-15-driven peripheral CD8+ T cell rescue in age-related cancer.
- 2026Mechanisticsuggestive
The GHK-Cu delays aging in Caenorhabditis elegans via coordinated regulation of mitochondrial function and activation of DAF-16/SKN-1 pathways
Wen H, Zhao K, Luo X, +3 · Biogerontology
The first mechanistic model-organism study to show GHK-Cu extends Caenorhabditis elegans lifespan via DAF-16 and SKN-1 activation coupled with restoration of mitochondrial fusion dynamics — a translational bridge between GHK-Cu's well-documented dermatological signal and the broader geroprotective hypothesis.
- 2020Mechanisticsuggestive
Pentadecapeptide BPC 157 Shortens Duration of Tetracaine- and Oxybuprocaine-Induced Corneal Anesthesia in Rats
Mirkovic I, Kralj T, Lozic M, +13 · Acta Clinica Croatica
BPC 157 eye drops fully reversed tetracaine- and oxybuprocaine-induced corneal anesthesia in rats and counteracted the lesions and tear-volume drop that the topical anesthetics caused — a Sikiric-group ocular paper published bilingually in a Croatian medical journal.
- 2015Mechanisticsuggestive
Epigenetic mechanisms of peptidergic regulation of gene expression during aging of human cells
Ashapkin VV, Linkova NS, Khavinson VKh, +1 · Biochemistry (Moscow)
The Khavinson program's 2015 epigenetic-mechanism paper for the KEDW tetrapeptide (Lys-Glu-Asp-Trp, Pancragen): DNA methylation patterns in aging pancreatic and bronchial cell cultures shift on selected promoters, and KEDW + AEDL are reported to modulate gene expression with tissue specificity — the closest the program has come to a published epigenetic mechanism for its short peptides.