Peptide encyclopedia
Every compound indexed here carries mechanism, route of administration, half-life, legal status, and the primary sources backing every claim — graded and dated.
- Compounds
- 75
- Source links
- 249
- Therapeutic classes
- 10
- Matching filter
- 13
F·Filter
Reset allGH secretagogue
Pulsed growth-hormone release via the GHRH / ghrelin pathways.
13 compounds
01
Prescription only
Anamorelin
ONO-7643 · RC-1291 · et al.
Anamorelin is the only ghrelin-receptor agonist with a regulatory approval for a muscle-wasting indication anywhere in the world — and the lean-mass-without-strength endpoint pattern that won Japan PMDA approval is the same pattern that produced an EMA refusal three years earlier.
Half-life·~6 to 7 hours plasma half-life with oral dosing, supporting …
Read entry
02
Research use only
CJC-1295
CJC-1295 with DAC · DAC:GRF · et al.
CJC-1295 with DAC produces 2- to 10-fold elevations in plasma GH for six days and 1.5- to 3-fold elevations in IGF-1 for nine to eleven days from a single subcutaneous injection — the longest sustained GH-axis stimulus of any peptide on this site.
Half-life·~6 to 8 days plasma half-life with the DAC moiety; the non-D…
Read entry
03
Research use only
GHRP-2
pralmorelin · GHRP-6 · et al.
GHRP-2 and GHRP-6 are first-generation ghrelin-receptor agonists with rich Bowers-group human pharmacology — and the cortisol, prolactin, and appetite spillover findings are the reason the modern selective-secretagogue stack moved to Ipamorelin instead.
Half-life·Plasma half-life roughly 20 minutes after intravenous admini…
Read entry
04
Research use only
Ghrelin
ghrelin · octanoyl-ghrelin · et al.
Ghrelin is the reference molecule for the entire ghrelin-mimetic class — every GHRP and small-molecule GHSR-1a agonist on this site is engineered to mimic some subset of its pharmacology, and native ghrelin's own clinical use remains essentially investigator-only six years past the molecular identification of its required acylation enzyme.
Half-life·Plasma half-life of the acylated form is approximately 10 to…
Read entry
05
Research use only
Hexarelin
Examorelin · EP-23905
Hexarelin has the deepest published human pharmacology of any GHRP — and the cortisol, prolactin, and tachyphylaxis findings are the reason the modern selective-secretagogue stack moved to Ipamorelin instead.
Half-life·Plasma terminal half-life approximately 55 minutes after int…
Read entry
06
Research use only
IGF-1 LR3
Long Arg3 IGF-1 · R3 IGF-1 · et al.
The molecule was engineered specifically to evade IGFBP sequestration and extend the free-active half-life of IGF-1 in circulation. The preclinical anabolic biology that follows from that engineering is well characterized. Published human pharmacology of IGF-1 LR3 specifically is essentially absent — the closest clinical evidence base is for native IGF-1 in pediatric growth-failure syndromes, a different molecule and a different population.
Half-life·Published practitioner literature and recombinant-protein ve…
Read entry
07
Research use only
Ipamorelin
NNC 26-0161
Ipamorelin's distinguishing feature is what it does not do — no meaningful elevation of cortisol, prolactin, or ACTH at doses 200-fold above the threshold for GH release.
Half-life·~2 hours plasma half-life; the GH pulse is brief but the dow…
Read entry
08
Prescription only
Long-acting somatropin (lonapegsomatropin, somapacitan, somatrogon)
lonapegsomatropin · Skytrofa · et al.
The three long-acting somatropins represent three distinct chemistry approaches to converting daily injections into weekly therapy — TransCon carrier release, fatty-acid albumin binding, and CTP fusion — and each is FDA-approved on the basis of non-inferiority against daily somatropin in narrow deficiency populations rather than on improved outcomes in healthy adults.
Half-life·Lonapegsomatropin releases unmodified somatropin with an eff…
Read entry
09
Research use only
MK-677
Ibutamoren · Ibutamoren mesylate · et al.
MK-677 is the GH-secretagogue most biohackers actually try, because it works orally — and the only one with a 65-patient two-year RCT (Nass et al., Annals 2008) measuring what daily dosing in older adults actually does.
Half-life·~4 to 6 hours plasma half-life with oral dosing; the GH and …
Read entry
10
Prescription only
Pegvisomant
Somavert · B2036-PEG · et al.
The only molecule on this site that lowers IGF-1 by blocking the growth-hormone receptor rather than suppressing the pituitary — and the only molecule whose efficacy can be monitored only by IGF-1, because circulating growth hormone rises during treatment by design.
Half-life·~6-day mean serum elimination half-life following single or …
Read entry
11
Prescription only
Sermorelin
GRF (1-29) · GHRH (1-29) NH2 · et al.
Sermorelin is the molecular grandfather of the GHRH-analog peptide class — the only one whose published RCTs sit in pediatric GH deficiency, and the only one whose modern biohacker-adjacent use case the original FDA file was never designed to test.
Half-life·~10 to 20 minutes plasma half-life after either intravenous …
Read entry
12
Prescription only
Somatropin
rhGH · growth hormone · et al.
Somatropin is the reference molecule for every GH-secretagogue claim on this site — the substance the secretagogues ask the pituitary to release more of, with the deepest evidence base, the narrowest approved indications, and the only criminal-statute restriction on off-label distribution of any prescription drug in U.S. law.
Half-life·~2 to 4 hours plasma half-life for daily subcutaneous somatr…
Read entry
13
Prescription only
Tesamorelin
Egrifta · Egrifta SV · et al.
The only peptide on this site with an FDA approval and a 412-patient placebo-controlled NEJM trial behind it — and even so, the indication it earned is narrow.
Half-life·~26 to 38 minutes plasma half-life; the GH and IGF-1 pulse i…
Read entry